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I know the meaning of this phrase I believe, it is used to give the most common or important example when you are abbreviating a list. I can't come up with anything that sounds really good as a translation.
Policy A, Policy B をはじめとする guidelines on the topic of X.
What I have at the moment is
Guidelines on the topic of X including Policy A and Policy B.
Policy A, Policy B ... をはじめとする
... the guidelines starting with Policies A, B, ...
... including / such as Policies A, B, ...
... guidelines, notably Policies A, B, ...
... guidelines, most notably Policies A, B, ...
... guidelines, the best examples being Policies A, B, ...
... guidelines[,] exemplified by Policies A, B, ...
... guidelines[,] whose list is headed by Policies A, B, ...
Policies A, B, ... and other guidelines
How about: Starting with policy A and policy B....
Think of と as an "assignment of value" particle.
はじめとする has the general meaning of "commencing/starting with" and is an irregular verb.
