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Is there a Japanese word or phrase for the chemistry in a relationship?

And by "relationship", I don't mean a strictly romantic one. It could be the chemistry between best friends, or even the lack of chemistry when meeting someone new and feeling like the two of you don't click.

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I would say that the most versatile counterpart would be 「相性{あいしょう}」. It can be used in any kind of interpersonal relationships including romantic ones.

We say:

「(Person A) + + (Peson B) + + 相性がいい。」 or

「(Person A) + + (Peson B) + + 相性が悪{わる}い。」

Every once in a while, you will encounter the word 「ケミストリー」, but it is not very common at all.

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